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During the initial weeks, patients may begin to notice subtle cognitive improvements, which can become more pronounced by weeks 6 to 8

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The nationwide fortification of grains with folic acid was estimated to prevent 1,000 cases of neural tube defects in the years after it was implemented, but a CDC study showed that there were still about 3,000 babies born with neural tube defects each year, even with the mandated fortification.[ref] ufficient choline, vitamin B12, vitamin B6, riboflavin, thiamine, zinc, and methionine (protein) also plays a role in reducing the risk of neural tube defects