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95 Across the setmelanotide clinical program, 1 patient with BardetโBiedl syndrome, fair skin (Fitzpatrick skin type II), freckling, nevi and a history of excessive sun exposure was diagnosed with stage pT1a melanoma after 3 years of continuous treatment (unpublished data, Rhythm Pharmaceuticals, Inc.) The lesion was excised for cure
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Both doses of alpha-lipoic acid moderately decreased self-reported pain compared to baseline, with somewhat better results at the higher dose, while there was no decrease in pain with placebo