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Among the various isoforms impacting chemoresistance, 169 GSTA1A (−567T, −69C, −52G) plays a role in the resistance to chlorambucil, while GSTA1B (−567G, −69T, −52A) is linked to resistance against busulfan and cyclophosphamide

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Kevin J Lenton, Alain T Sané, Hélène Therriault, André M Cantin, Hélène Payette, J Richard Wagner - Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency - Am J Clin Nutr - 2003 Jan