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The number of self-reported current somatic diseases (including cardiometabolic, respiratory, musculoskeletal, digestive, neurological, endocrine diseases and cancer) for which participants received medical treatment was counted (coded as 0, 1, 2+) as a global marker of poor physical health

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In this model, the KD from one JAK2 molecule bound to a Box1–Box2 motif from one receptor is inhibited by interacting with the PKD from a different JAK2 molecule bound to the opposing receptor within the receptor homodimer