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Therapeutic strategies targeting this axis (Figure 2), such as BH4 supplementation, NOX inhibitors, and lifestyle modifications (e.g., exercise, Mediterranean diet), aim to restore redox balance and endothelial function, though their efficacy varies by HTN stage and comorbidities

Neurogenic

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Sermorelin is a short-chain peptide fragment of GHRH that acts as a GH secretagogue, meaning it prompts the pituitary gland to produce more growth hormone