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Folate is also important in the mitochondria, but those folate-dependent reactions rely on SHMT and 1-formyl-THF instead of MTHFR and methylfolate.[ref] The MTHFR C677T and A1298C variants: Two common variants in the MTHFR gene, C677T and A1298C, cause the enzyme not to function normally

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Ocular ischemia, another risk factor for cataract development, is characterized by vision loss, orbital pain, and changes of the visual field