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Epitalon demonstrated its strongest interaction with histone H1/6, forming 12 docking solutions at site 5 and binding with the lowest energy recorded in the study: −64.51 kcal/mol at the sequence Tyr-Arg-Lys-Thr-Gln

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In IBS, this equilibrium is disturbed, as dysbacteriosis, increased gut permeability, visceral hypersensitivity, and mucosal microinflammation are present