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The smaller the expected impact a model is hypothesized to achieve, the larger a model needs to be for CMS to have confidence in the observed impacts

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Some contraindications (reasons not to take B12 shots) include: Allergies to cyanocobalamin or methylcobalamin Kidney or liver disease Eye issues, especially if you have Leber’s disease A current infection If you’re taking medication related to bone marrow You should talk to your doctor about the above conditions before getting B12 injections