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Fennema D, Phillips IR, Shephard EA Drug metabolism and disposition: the biological fate of chemicals 2016

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The two compounds stimulate GH release through completely distinct and complementary intracellular signalling pathways , CJC-1295 Without DAC activating the adenylyl cyclase/cAMP/PKA pathway through GHRH receptor engagement, and Ipamorelin activating the phospholipase C/IP3/calcium mobilisation pathway through GHS-R1a engagement