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[5] Small-molecule NNMT inhibitors were then developed to reproduce that effect pharmacologically: in cultured adipocytes, 5-Amino-1MQ-type inhibitors lowered 1-methylnicotinamide, raised intracellular NAD⁺ and SAM, and suppressed lipogenesis

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While strategies such as vitamin supplementation and food fortification are considered promising approaches to mitigate these deficiencies, further research is recommended to develop targeted public health interventions (328)