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Table of Contents Thyroid hormones are the master regulators of metabolic processes throughout the body, including: The synthesis of thyroid hormones is regulated by the hypothalamus and pituitary glands, which secrete TRH and TSH, respectively, to stimulate thyroid hormone production and release from the thyroid gland in response to low thyroid hormone levels or other stimuli, including cold exposure and various stressors.² Production of TRH and TSH is controlled by negative feedback mechanisms, including sufficient thyroid hormone level and somatostatin