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The spatial conformation and secondary structure parameters of BPC-157 are heavily influenced by intramolecular hydrogen bonding networks and the strategic placement of hydrophobic and hydrophilic amino acid residues along the chain.

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Similarly, reduced activity of the Leu allele compared to the Pro allele was reported in transfected bovine aortic endothelial cells, suggesting that differences between these polymorphic forms may affect GPx-1 activity in many different cell types (152)