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[19] Diagnosis [edit] Graves' disease may present clinically with one or more of these characteristic signs: [20] [21] Tachychardia Goiter Tremor Exophthalmos (protuberance of one or both eyes), periorbital edema Fatigue, weight loss with increased appetite in young people and poor appetite in the elderly, and other symptoms of hyperthyroidism/thyrotoxicosis Heat intolerance Tremulousness Palpitations Two signs are truly diagnostic of Grave's disease (i.e., not seen in other hyperthyroid conditions): exophthalmos and non-pitting edema (pretibial myxedema)

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TB-500’s primary mechanism operates through G-actin sequestration — by binding free G-actin monomers, TB-500 promotes cytoskeletal reorganisation that drives cell motility