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[13] [19] Specifically, the function of GSTs in this role is twofold: to bind both the substrate at the enzyme's hydrophobic H -site and GSH at the adjacent, hydrophilic G-site, which together form the active site of the enzyme

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The main precautionary note for GHK-Cu concerns individuals with known copper metabolism disorders or Wilson’s disease, for whom any additional copper loading, including from GHK-Cu, would be contraindicated