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(6) Complex I: Complex I (NADH:ubiquinone oxidoreductase) is a large multiprotein complex located in the mitochondrial inner membrane that accepts electrons from NADH and transfers them to ubiquinone (CoQ 10 ) via FMN and a series of iron–sulfur (Fe–S) clusters, reducing it to ubiquinol (CoQ 10 H 2 ) 68,69

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The first regulatory layer involves DNA methylation, the addition of a methyl group to cytosine bases (typically in CpG promoter regions), which generally represses gene transcription