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PRL levels within the physiological or “metabolic” range can promote β-cell proliferation and survival, improve insulin sensitivity, inhibit gluconeogenesis, optimize lipid distribution, and reduce the risk of fatty liver disease ( 7 Clinical implications and future directions 7.1 Therapeutic considerations in patients with obesity and hyperprolactinemia Currently, weight management strategies are divided into three categories: lifestyle interventions, drug therapy, and metabolic/bariatric surgeries