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If weekly dosing is a protocol constraint, consider sustained-release formulations (e.g., PLGA microspheres) or dose-stacking: administer 3× the standard daily dose weekly, accepting that receptor activation will be supra-physiologic for the first 12 hours post-injection and sub-threshold for days 5–7

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Galactose modified prodrugs Duocarmycin Senescent cells are characterized by high levels of (SA-β-Galactosidase) implying that generation of prodrugs combining a cytotoxic compound linked to a cleavable galactose part should be preferentially processed by those cells