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In the reversing reperfusion stroke, after 60 min, mRNA expression studies at 1 and 24 h reperfusion time provided strongly elevated (Egr1, Akt1, Kras, Src, Foxo, Srf, Vegfr2, NOS-3, and NOS-1) and decreased (NOS-2, Nfkb) gene expression (Mapk1 not activated) in rats that received BPC 157 therapy following reperfusion, as a way of showing how BPC 157 may act [145]