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Hair pigmentation is regulated by melanogenesis within the follicle and modulated by various factors, including melanocyte-stimulating hormone (MSH), adrenocorticotropic hormone (ACTH), endothelin-1, prostaglandins, leukotrienes, fibroblast growth factors, nitric oxide, catecholamines, as well as essential vitamins and minerals

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A retrospective analysis of a national medical records database (2017/2018, n = 473 patients) revealed that 40% of women with IPTB delivered within 48 h, justifying the initial NAC iv -infusion for the severe IPTB subgroup to maximize efficacy, due to NAC’s rapid placental transfer