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Data availability Raw 16S rRNA bacterial sequence data (fastq files and metadata) is available from NCBI through BioProject Accession number PRJNA1189833

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Altogether, the findings identified key aging-related differentially expressed genes in multiple cell types that may underly the phenotype of hippocampal aging, characterized by increased heterochromatin erosion, genomic instability, cytosolic Amyloid-beta aggregation, inflammation and senescence and decreased neurogenesis