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It is a substrate for α-ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting α-KG to isocitrate

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The blood-brain barrier degrades or excludes most of them efficiently

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