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Before advancing these strategies to clinical application, several key challenges must be addressed, such as the complexity and functional redundancy of the ferroptosis regulatory network, the limitations of existing animal models in simulating the pathological features of human chronic OA, and the lack of reliable biomarkers for assessing intra-articular ferroptosis activity in humans

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Some peptides, particularly BPC-157 and Larazotide, have shown promise for the inflammation and barrier-function pathways that often drive IBS symptoms