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These superoxide radicals (O 2 •–) come from NADPH oxidase (NOX) and the mitochondrial electron transport chain (ETC).Mechanistically, nonenzymatic lipid peroxidation starts when OH • derived from the Fenton reaction extracts hydrogen atoms from the double-bonded carbon atoms of PUFAs, forming phospholipid radicals (PL • ) with a carbon-centered structure

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