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These pathway-level predictions were experimentally validated, as PYC significantly suppressed IL-6 and IL-1β expression in lipopolysaccharide-induced BV2 microglial cells, supporting its multi-component, multi-target mode of action (Liu et al., 2024)

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For instance, GPX3 expression was found to be elevated in the serum of overweight and obese individuals in central Mexico, with serum GPX3 concentration positively correlating with body weight and inversely correlating with insulin sensitivity [137]

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