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Steroids provide short-term relief but are toxic to tendons, ligaments, and cartilage with repeated use

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In the same time-course study (Figure 3a and b), we also found that p62 mRNA could be already induced 2 h after the application of the drugs (Figure 4d) but the protein level changes only happened at 8 and 16 h (Figure 3b), suggesting the upregulation of p62 was the subsequent effect of LC3II induction