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The peptide's cognitive enhancement mechanism operates through hepatocyte growth factor (HGF) pathway potentiation, which is distinct from traditional nootropic mechanisms and represents a novel approach to cognitive enhancement research focused on structural brain plasticity

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Genetic polymorphisms in NMDAR subunits, such as NR1 and NR2B, influence individual sensitivity to the therapeutic and toxic effects of ketamine (Smith-Apeldoorn et al., 2022)