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These can occur with or without anaemia and may include: tiredness, weakness or lack of energy pins and needles or numbness muscle weakness problems with balance or coordination memory or concentration difficulties changes in mood loss of appetite visual symptoms These symptoms can have many different causes and should not automatically be assumed to be due to vitamin B12 deficiency

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ASOs offer several advantages compared to viral-based approaches - their inherent degradability and short half-lives (ranging from weeks to months, depending on formulation) allow for adjustable dosing and reversible effects, reducing the risk of prolonged off-target effects