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Therapeutic response to cyanocobalamin may decrease due to elderly age, infection, renal insufficiency, diabetes mellitus, marrow suppressants use (e.g

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In animals with established bleomycin-induced injury, the authors reported reduced TGF-beta-1 levels, altered markers associated with epithelial-to-mesenchymal transition, and changes in histological fibrosis scoring in GHK-exposed animals relative to controls, attributing the observations to modulation of TGF-beta-1/Smad signaling