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Cohen deemed MOTS -c promising enough that he founded a company to take it into a Phase I clinical trial—an early step on the road toward F.D.A

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The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion — establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models