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Although some transport of glutathione S -conjugates may occur across the sinusoidal membranes (e.g., Inoue et al., 1984a, Inoue et al., 1984b), the major route for the removal of these compounds in the rat liver is via canicular transporters into the bile (e.g., Akerboom et al., 1991, Hinchman et al., 1998, Keppler and König, 2000, Vore, 1993)