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The peptide naturally occurs in human plasma at approximately 200 ng/mL at age 20, but declines to about 80 ng/mL by age 60

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… The precision of this mechanism is a key advantage, as it minimises collateral damage to surrounding tissues.” (Peptide Gurus) Summary of findings In summary: FOXO4-DRI has been shown to reduce senescent cell number in animal models and cell culture