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A distinct lysophospholipase enzyme, abhydrolase domain-containing protein 12 (ABHD12), cleaves PUFA-containing lysophosphatidylserine and oxidized phosphatidylserines specifically, and inhibition of this enzyme is sufficient to increase PUFA-phosphatidylserine (that is, 18:0/20:4 phosphatidylserine) levels and boost ferroptosis sensitivity

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(PubMed) Eshak ES, Iso H, Yamagishi K, Cui R, Tamakoshi A