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Mechanistic pathways associated with acetaminophen-induced hepatotoxicity APAP is rapidly absorbed and extensively metabolized upon entering the liver, with 85–90% conjugated with glucuronic acid or sulfate by the enzymes uridine diphosphate-glucuronosyltransferase and sulfotransferase and subsequently eliminated

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Jan 12 2021;22(2)doi:10.3390/ijms22020676 De Stefano V